Vinyl chloride is also a known genotoxicant, causing chemical alterations of DNA in tissues that may lead to cancer following exposure of humans and experimental animals (1, 2). Vinyl Chloride is listed by the U.S. Department of Health and Human Services National Toxicology Program (NTP) as a known human carcinogen, by the International Human carcinogen -- Vinyl Chloride: Vinyl Chloride is deemed to be carcinogenic to humans. Chronic exposure can cause permanent liver injury and liver cancer, neurologic or behavioral symptoms and changes to the skin and bones of the hand. The primary cause of Human carcinogen -- Vinyl Chloride is the result: at any time, from exposure to toxins, poisons, environmental, or other substances. The International Agency for Research on Cancer has determined that vinyl chloride is carcinogenic to people, and EPA has determined that vinyl chloride is a human carcinogen. Vinyl bromide appears to be a more potent inducer of hepatic hemangiosarcoma in rats than is vinyl chloride. Vinyl chloride is used primarily to make PVC, a substance used in products such as pipes. Vinyl chloride is released into the environ- ment in emissions and effluents from the plastics industry. Vinyl chloride Toxicological overview Key Points Kinetics and metabolism ... (IARC), vinlyl chloride is a recognised human carcinogen. In the case of permitted digital reproduction, please credit the National Cancer Institute as the source and link to the original NCI product using the original product's title; e.g., “Vinyl Chloride was originally published by the National Cancer Institute.”, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Emotional Support for Young People with Cancer, Young People Facing End-of-Life Care Decisions, Late Effects of Childhood Cancer Treatment, Tech Transfer & Small Business Partnerships, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Step 1: Application Development & Submission, U.S. Department of Health and Human Services. This process is experimental and the keywords may be updated as the learning algorithm improves. Vinyl chloride is classified as Group 1 carcinogen by the IARC, meaning it is seen as a definite cause of cancer in humans. 63. Vinyl Chloride (VC) is a proven human carcinogen and a major risk factor in many contaminated aquifers. Vinyl chloride is a highly dangerous chemical used to make numerous plastic materials. Vinyl chloride is a colorless gas that burns easily. Vinyl Chloride is a known human carcinogen. 1978), which suggests that vinyl bromide’s greater carcinogenic potency may be related to kinetic differences in metabolism. Spread the word and invite others to become a friend of the roadmap. Vinyl Chloride Carcinogenic Potency Dose Response Data Animal Colony Fisher Exact Probability Test These keywords were added by machine and not by the authors. Employers shall include vinyl chloride in the hazard communication program established to comply with the HCS (§1910.1200). Vinyl chloride does not occur in the environment naturally. Together we can make a difference. But also in occupations or services allied to transport and construction. (2) • EPA has classified vinyl chloride as a known human carcinogen by the inhalation route of exposure. Latency period between exposure and vinyl chloride related cancers varies strongly depending on the different types of cancer. The carcinogenicity of the substance may be influenced by the nature (e.g. Wang Q, Ji F, Sun Y, Qiu YL, Wang W, Wu F, et al. Vinyl chloride (VC) is a human carcinogen that accumulates in soil and groundwater due to incomplete dechlorination of chlorinated ethenes. EPA has classified vinyl chloride as a Group A, human carcinogen. vinyl chloride (by about an order of magnitude) (Bolt et al. Trichloroethylene (TCE) is a ubiquitous contaminant classified as a human carcinogen. Some strains of obligate organohalide respiring Dehalococcoides mccartyi can synthesize the VC reductase that catalyzes the dechlorination of VC to ethene. Perform proper exposure measurements so it is known when actions should be taken. When present above the maximum concentration level (MCL) of 2 ppb, sites are unable to close and require continued remediation and monitoring. Uses [of PolyVinyl Chloride] Most of the vinyl chloride produced in the United States is used to make polyvinyl chloride (PVC), a material used to manufacture a variety of plastic and vinyl products including pipes, wire and cable coatings, and packaging materials. Vinyl chloride is a colorless gas that burns easily. The primary target organ for vinyl chloride exposure is the liver (1, 2). Industries at risk are manufacture of industrial chemicals, plastic products, fabricated metal products or machinery. The environ- ment in emissions and effluents from the plastics industry Group,... For guidance about copyright and permissions: Systems Biology in Toxicology and Environmental and... 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