Levels above 200 pg/ml are considered high. If you are suffering from PCOS (7), infertility or some other condition that may cause variation in the normal typical cycle then this must be taken into account when testing for estrogen. You can find more information about me here. E2 levels should be within the reference range for premenopausal women, LH/FSH should be within the normal range, and E2 levels should ideally be higher than E1 levels. With women, it also depends upon their menstrual cycle or whether they are pregnant. Normal estrogen results depend upon the sex and age of the person being tested. Are your lab tests confusing? E2 levels should be within the reference range for premenopausal women, LH/FSH should be within the normal range, and E2 levels should ideally be higher than E1 levels. The normal level will depend on things such as age and time of life. You can find a list of low estrogen symptoms below: Low estrogen is generally easier to diagnose and spot via lab testing than high estrogen, but if you are experiencing any of these symptoms AND you have low (even low-normal) estradiol levels in the serum then you are likely experiencing low estrogen. Low testosterone and elevated estrogen increase the incidence of erectile dysfunction independently of one another. Learn more about what constitutes normal estrogen levels in this guide including how to determine if your levels are normal and what to do about it: Estrogen is a class of hormones which are very important to both men and women. Copyright © 2021 Leaf Group Ltd., all rights reserved. Monitor serum testosterone and estradiol at follow-up visits with a practical target in the female range (testosterone 30 – 100 ng/dl; E2 <200 pg/ml). Certain hormones have the ability to sit on and activate estrogen receptors in the body which turn on genetic function (1). Some other treatments may include estrogen replacement therapy and alternative medications. Once levels are evaluated, treatment may help to alleviate symptoms of the hormonal imbalances. Nicole Long is a freelance writer based in Cincinnati, Ohio. It is determined by collecting data from vast numbers of laboratory tests. * These statements have not been evaluated by the Food and Drug Administration. Serum concentrations of estradiol in azoospermic or … Gordon CM, Ackerman KE, Berga SL, et al. If you have questions regarding your health you should seek qualified information from a medical professional or your doctor. It's often the case that your estrogen levels may show up "normal" even in the face of these types of symptoms. It serves many purposes including helping to regulate the menstrual cycle, preserving bone density and increasing uterine growth. You can find more information about our return and refund policies here. Birth control pills may affect the results of a serum estradiol test. If normal is 20-40 what kind of test am I looking at … This product is not intended to diagnose, treat, cure or prevent any disease. This can be caused by menopause, anorexia and Turner Syndrome. Saliva Estrogen Levels. Estrogen is the dominant female hormone and fluctuates during different times in the menstrual cycle and as you age. The second rule is only test your estradiol:progesterone ratio during the mid-luteal phase of your cycle. Estrogen replacement therapy has seen a decrease in use due to the possible link between it and uterine cancer, heart disease and stroke. Treatment for estrogen imbalance will include exercise and eating a healthy diet. Whats up everybody just needed some input as my endo says my total serum essay doesnt really matter because its never right on the tests its my e2 i should be worried about. This variation NEEDS to be taken into account when testing estrogen. During puberty, normal levels fall between 23 and 84 pg/ml. For this reason, you should always pair up how you are feeling clinically with what your labs show. The fewest deaths occurred when estradiol levels were between 21.8 and 30.11 pg/ml. Estradiol is the most potent of this group (3). If you get your labs drawn at any other time then this ratio won't help guide you. There would be no way to know what is actually your normal unless you have a baseline testing of estrogen (which is unlikely), All of these factors will influence estradiol (and thus estrogen) levels in your body and may cloud the picture, The principal cause of low estrogen is menopause which tends to occur in the fifth decade of life, Absolute numbers (either high or low) tend to have value when they fall outside of the reference range provided by the lab company, but you will find that most women who suffer from symptoms often have "normal" lab tests, © 2021 Dr. Westin Childs | Thyroid & Health Supplements That Work, How & When to Use Progesterone Pills (Prometrium): Pros & Cons & More, The Connection Between Hypothyroidism and Depression (+Treatment). In normal reproductive age women, during the menstrual cycle, estradiol levels range from 50-400 pg/ml. Interpretation. Please contact us here. Estrogen levels are considered low when the range is 10 to 20 pg/ml. If your estradiol is 50, you'll want your progesterone to be around 5 and so on. His focus is on managing thyroid disorders, weight loss resistance, and other sex hormone imbalances. But just realize that there are MANY other "estrogens" floating around in your body which are not being tested and which may have an impact on your body. Serial samples must be collected over several days to evaluate baseline and peak total estrogen levels. What if you are taking an estrogen-blocking medication? Typically a women aged 20 to 29 will have an average level of 149 pg/ml (pictograms per milliliter). So if your estradiol is 100, you'll want your progesterone to be somewhere around 10. Weight gain (12), insulin resistance (13), thyroid disease (14) and PCOS all tend to cause changes in the body which result in higher than normal estrogen (estradiol). ... To interpret test results use the reference range in the laboratory report. It consists of three fractions: Estrone, which maily occurs after menopause; estradiol, which is produced in the ovaries and is responsible for ovulation and affects conception and pregnancy; and estriol, which commonly occurs during pregnancy. The best way to assess estrogen is in combination with progesterone, the other vital sex hormone. Estrogen replacement in reproductive age women should aim to mimic natural estrogen levels as closely as possible. Estrogen levels can be elevated because of obesity, cardiovascular disease and digestive problems. The normal range of estrogen varies depending upon the patient's age. So if your estradiol is 100, you'll want your progesterone to be somewhere around 10. Below you will find a list of tests that you should get for both men and women: If there are continued issues (or the picture still isn't clear) then you would want to evaluate other estrogen metabolites with urinary tests to see how well your body is handling estrogen. The serum testing is not helpful if you use creams as estrogen levels do not rapidly cross into the serum. The principal cause of low estrogen is menopause which tends to occur in the fifth decade of life. And those over 40 but not in menopause will have an average level of 152 pg/ml. I feel fine I think. Read more about our affiliate disclosure here. Normal estrogen levels in men help prevent cardiovascular disease and heart attacks. Estrogen and progesterone balance is critical to maintaining normalcy among women. If you are experiencing the symptoms of high or low estrogen then there's a high probability that you have an estrogen balance issue. Or that having low progesterone may mimic the symptoms of high estrogen? Low levels of estrogen can leave you feeling depleted and exhausted. Or have they been helpful? Hey There! These estrogens are then cut up and metabolized into smaller fragments by the liver and each of these fragments also has an impact on estrogen receptors in the body. Read more here. Reference ranges will vary somewhat between laboratories, both in normal values listed and in units used. The test said I was in range and nothing was abnormal but you know how that goes. Cleveland Clinic. She earned her Bachelor of Arts degree in economics from the University of Cincinnati. Let's say that you are suffering from some symptoms, such as menstrual irregularities, which leads you to the Doctor for testing. Because it is known that estrogen varies based on the day of the month (assuming a normal menstrual cycle) lab tests come equipped with "ranges" which are designed to help with interpretation. Lab testing can be helpful, but in order for you to be able to get actionable information from your lab testing, you have to follow a couple of rules. This ratio of 10:1 only holds true during the mid-luteal phase of the menstrual cycle (days 19-21). This is just one way in which testing for estrogen is not as straightforward as it might seem. What if you are on birth control medication? Sit down and dig into these posts. For a prepubescent male, estrogen levels are expected to be between 10 and 37 picograms per milliliter (pg/ml). Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline. You can read more about his own personal journey here. We do have ways to assess estrogen in your body, but often these values should be used in context with your symptoms to help complete the picture. Harvard Health Letter. This will give you the most information compared to randomly assessing estradiol by itself. These average levels can vary day to day depending on each female's menstrual cycle. Also, in the penis, estrogen receptors are found. Total estrogen , serum: 3074.4 pg/ml Estradiol: <15 ph/ml Testosterone: 704 ng/dL. im having pretty much every high estrogen symptom. Depends: The normal levels are determined by the lab doing the test. If you go into your Doctors office and your Doctor orders an estrogen on just some random day, it's almost impossible to make any sort of claim based on that single lab test about your estrogen level. Serum estradiol levels were measured in 360 men attending an infertility clinic and 68 proven fertile men to determine whether estradiol measurements are clinically useful. If you are between the ages of 20 and 29, it is expected that a woman will have an estrogen level of 149 pg/ml. So how are you supposed to navigate this complex problem of estrogen testing? This is where the ratio of progesterone:estradiol comes in handy. E2 levels should be within the reference range for premenopausal women, LH/FSH should be within the normal range, and E2 levels should ideally be higher than E1 levels. That’s because this hormone fuels changes in a young girl's body. Estrogens, Fractionated, Serum 36742X Clinical Use • Assess estrogen status Reference Range Interpretive Information • Ovarian tumors • Feminizing adrenal tumors • Precocious puberty • Ovarian failure • Postmenopausal • Gonadotropin deficiency Clinical Background Estrogens are 18-carbon steroids secreted by the gonads, adrenal glands, Estrogen is an important hormone which fluctuates based on the day of the month and the age of the patient. In adult women who experience regular menstrual cycles (premenopause), normal estradiol levels range between 15 and 350 picograms per milliliter (pg/mL). Estrogen is really a broad term which is used to describe an array of hormones which activate estrogen receptors on your cells, the most potent of which is estradiol. Estradiol is a female sex hormone required for the normal development and functioning of the reproductive system. The problem with these lab tests (as pointed out below) is that the reference range is very wide (6): You can see from this example that mid-follicular phase estrogen may vary from 27 to 123. A simple blood, urine or saliva sample can be evaluated to determine estrogen levels. Published June 2010. Evaluate for ovarian estrogen producing tumor in the premenarcheal and postmenopausal female; evaluate estrogen excess in males. Once you have determined if your estrogen is high or low you can then start to target your treatment. It turns out that there really isn't a hormone in the body called "estrogen", instead estrogen is used to refer to a series of hormones which act on estrogen receptors. The normal range of estrogen varies depending upon the patient's age. Any thoughts on this and anything I should look out for? There would be no way to know what is actually your normal unless you have a baseline testing of estrogen (which is unlikely). Other conditions, such as the removal of ovaries or the use of anastrozole, can trigger menopausal-like symptoms in women and lead to symptoms of low estrogen as well. Are you suffering from the symptoms of high or low estrogen? ESTF : Estrogens are involved in development and maintenance of the female phenotype, germ cell maturation, and pregnancy. You can learn more about this condition, including what causes it and how to treat it here. What is considered a "normal estrogen level"? If your Doctor tests your estrogen and you come back in the normal range for the mid-luteal phase estrogen with a value at 58 you may be considered "normal". It's important to reduce levels of estrogen to normal levels because high levels of estrogen also are associated with breast and uterine cancer. This content is strictly the opinion of Dr. Westin Childs and is for educational and information purposes only. The first is to always order estradiol in combination with progesterone. Even more important, the timing of the test relative to the menstrual cycle has a large impact on the amount of estrogen she is producing. And those over 40 but not in menopause will have an average level of 152 pg/ml. Oral birth control medication blocks the natural production of FSH and LH from the pituitary gland which can effectively shut off the production of endogenous progesterone and estrogen in your body (8). Monitor prolactin and triglycerides before start- ing hormones and at follow-up visits. You are the single best way to determine if your levels are normal or abnormal. Published May 24, 2018. 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